| Week One |
|---|
| Home | Opponents | Venues | Playoffs, etc | Alumni |
|---|
| Year | Week | Date / Time | Opponent | Venue | Score | Result | Notes |
|---|---|---|---|---|---|---|---|
| 1956 | 1 | 09/14 Fri 20:00 | Shawen Acres | Shawen Acres | 0-18 | L | First game |
| 1957 | 1 | 09/13 Fri 20:00 | Shawen Acres | Shawen Acres | 30-0 | W | |
| 1958 | 1 | 09/12 Fri 20:00 | Ansonia | Shawen Acres | 24-0 | W | |
| 1959 | 1 | 09/18 Fri 20:00 | Germantown | Germantown | 20-42 | L | |
| 1960 | 1 | 09/17 Sat 13:30 | Germantown | Wayne | 28-6 | W | First true Home game |
| 1961 | 1 | 09/16 Sat 13:30 | Xenia Woodrow Wilson | Wayne | 18-18 | T | Pat Garland 7-yd run with 30 seconds remaining for the tie (PAT attempt (run) failed) |
| 1962 | 1 | 09/07 Fri 20:00 | Northridge | Northridge | 24-8 | W | |
| 1963 | 1 | 09/06 Fri 20:00 | Northridge | Northridge | 14-12 | W | |
| 1964 | 1 | 09/11 Fri 20:00 | Northridge | Northridge | 63-30 | W | Originally scheduled at Wayne, moved to Northridge due to WHS lights not being ready; School records: Points Scored, Rushing Yards (414), Passing Yards (242), Total Offense (656 yds); First Downs (24) |
| 1965 | 1 | 09/10 Fri 20:00 | Northridge | Wayne | 23-14 | W | |
| 1966 | 1 | 09/09 Fri 20:00 | Northridge | Wayne | 22-0 | W | |
| 1967 | 1 | 09/08 Fri 20:00 | Northridge | Northridge | 13-0 | W | |
| 1968 | 1 | 09/06 Fri 20:00 | Northridge | Wayne | 35-0 | W | |
| 1969 | 1 | 09/05 Fri 20:00 | Northridge | Northridge | 42-0 | W | |
| 1970 | 1 | 09/11 Fri 20:00 | Toledo Woodward | Wayne | 19-20 | L | |
| 1971 | 1 | 09/10 Fri 20:00 | Colonel White | Wayne | 12-6 | W | |
| 1972 | 1 | 09/08 Fri 20:00 | Colonel White | Wayne | 27-6 | W | |
| 1973 | 1 | 09/07 Fri 20:00 | Colonel White | Wayne | 29-0 | W | |
| 1974 | 1 | 09/06 Fri 20:00 | Colonel White | Wayne | 31-0 | W | |
| 1975 | 1 | 09/05 Fri 20:00 | Wilbur Wright | Wayne | 9-28 | L | |
| 1976 | 1 | 09/10 Fri 20:00 | Wilbur Wright | Wayne | 33-10 | W | |
| 1977 | 1 | 09/09 Fri 20:00 | Northmont | Northmont | 0-31 | L | |
| 1978 | 1 | 09/08 Fri 20:00 | Northmont | Wayne | 7-21 | L | |
| 1979 | 1 | 08/31 Fri 20:00 | Northmont | Northmont | 0-44 | L | |
| 1980 | 1 | 08/29 Fri 20:00 | Northmont | Wayne | 6-50 | L | |
| 1981 | 1 | 09/04 Fri 20:00 | Northmont | Northmont | 7-13 | L | Mike Schneider's first game |
| 1982 | 1 | 09/03 Fri 20:00 | Vandalia Butler | Wayne | 15-9 | W | |
| 1983 | 1 | 09/02 Fri 20:00 | Vandalia Butler | Vandalia Butler | 16-13 | W | |
| 1984 | 1 | 08/31 Fri 20:00 | Vandalia Butler | Wayne | 45-7 | W | Jeff Dix ties school record with 3 TD receptions; Kevin Swords ties school record with 6 PATs kicked |
| 1985 | 1 | 08/30 Fri 20:00 | Vandalia Butler | Vandalia Butler | 21-6 | W | |
| 1986 | 1 | 08/29 Fri 20:00 | Northmont | Wayne | 34-25 | W | |
| 1987 | 1 | 09/04 Fri 19:30 | Northmont | Northmont | 41-23 | W | |
| 1988 | 1 | 09/02 Fri 19:30 | Northmont | Wayne | 38-0 | W | |
| 1989 | 1 | 08/25 Fri 19:30 | Northmont | Northmont | 26-23 | W | |
| 1990 | 1 | 08/24 Fri 19:30 | Cincinnati Elder | Wayne | 0-30 | L | Broke Wayne's 30 game home winning streak dating back to 1983 |
| 1991 | 1 | 08/30 Fri 19:30 | Middletown | Wayne | 14-35 | L | |
| 1992 | 1 | 09/04 Fri 19:30 | Middletown | Middletown | 10-31 | L | |
| 1993 | 1 | 09/03 Fri 19:30 | Lakota | Wayne | 14-0 | W | |
| 1994 | 1 | 09/02 Fri 19:30 | Lakota | Lakota | 14-10 | W | |
| 1995 | 1 | 09/01 Fri 19:30 | Lakota | Wayne | 20-24 | L | |
| 1996 | 1 | 08/30 Fri 19:30 | Lakota | Lakota | 7-13 | L | |
| 1997 | 1 | 08/29 Fri 19:30 | Lakota East | Wayne | 39-48 | L | Boyd (Lakota East) 305 rushing yards, 4 TDs |
| 1998 | 1 | 09/04 Fri 19:30 | Lakota East | Lakota East | 7-24 | L | |
| 1999 | 1 | 08/27 Fri 19:30 | Lakota East | Wayne | 44-10 | W | Earnest Tucker 222 yds rushing |
| 2000 | 1 | 08/25 Fri 19:30 | Cincinnati Princeton | Wayne | 21-24 | L | OT |
| 2001 | 1 | 08/24 Fri 19:30 | Lakota East | Wayne | 21-0 | W | Wayne forced five turnovers |
| 2002 | 1 | 08/23 Fri 19:30 | Lakota East | Lakota East | 7-17 | L | |
| 2003 | 1 | 08/22 Fri 19:30 | Cincinnati Oak Hills | Wayne | 13-21 | L | |
| 2004 | 1 | 08/27 Fri 19:30 | Cincinnati Oak Hills | Oak Hills | 28-14 | W | |
| 2005 | 1 | 08/27 Sat 19:15 | Cincinnati Elder | UC Nippert Stadium | 14-21 | L | Skyline Chili Crosstown Showdown |
| 2006 | 1 | 08/24 Thu 19:30 | Cincinnati St. Xavier | St. Xavier Ballaban Field | 14-52 | L | Skyline Chili Crosstown Showdown
St. X defending state champs Originally scheduled for Sat at Nippert Moved to Thu due to teacher's strike |
| 2007 | 1 | 08/24 Fri 20:15 | Cincinnati Colerain | Miami Yager Stadium | 7-19 | L | Skyline Chili Crosstown Showdown |
| 2008 | 1 | 08/21 Thu 20:15 | Lakota West | Welcome Stadium | 20-17 | W | Skyline Chili Crosstown Showdown Garrett Klink 20 yd fieldgoal w/ :04 left |
| 2009 | 1 | 08/28 Fri 20:30 | Cincinnati Princeton | Welcome Stadium | 21-4 | W | Skyline Chili Crosstown Showdown |
| 2010 | 1 | 08/29 Sun 19:00 | Cincinnati Moeller | St. Xavier Ballaban Field | 28-35 | L | Skyline Chili Crosstown Showdown (ESPNU) |
| 2011 | 1 | 08/27 Sat 19:30 | Middletown | Welcome Stadium | 31-32 | L | Skyline Chili Crosstown ShowdownJavon Harrison stopped on 2-pt try with 1:05 remaining |
| 2012 | 1 | 08/25 Sat 17:30 | Cincinnati Winton Woods | Welcome Stadium | 30-20 | W | Skyline Chili Crosstown Showdown |
| 2013 | 1 | 08/30 Fri 19:00 | Gahanna Lincoln | Wayne | 62-28 | W | D'Mitrik Trice: school record 6 TD passes (only played the first half); 48-7 at halftime |
| 2014 | 1 | 08/29 Fri 19:30 | Gahanna Lincoln | Gahanna Lincoln | 40-0 | W | |
| 2015 | 1 | 08/28 Fri 18:00 | Canada Prep | Wayne | 38-0 | W | Backyard Blitz |
| 2016 | 1 | 08/26 Fri 19:00 | Archbishop Wood (PA) | Wayne | Backyard Blitz, Cancelled due to lightening | ||
| 2017 | 1 | 08/27 Sun 13:30 | Pine-Richland (Gibsonia, PA) | Pine-Richland | 0-41 | L | ESPN High School Kickoff |
| 2018 | 1 | 08/24 Fri 19:00 | Knoxville Austin-East (TN) | Wayne | 56-20 | W | |
| 2019 | 1 | 08/30 Fri 19:00 | Cincinnati Colerain | Wayne | 19-28 | L | Backyard Blitz |
| 2020 | 1 | 08/28 Fri 19:00 | Springfield | Springfield | 14-21 | L | |
| 2021 | 1 | 08/20 Fri 19:00 | Dunbar | Welcome Stadium | 41-7 | W | |
| 2022 | 1 | 08/19 Fri 19:00 | Fairfield | Fairfield | 24-41 | L | Skyline Chili Crosstown Showdown Thursday Night Lights (Channel 22.3) |
| 2023 | 1 | 08/18 Fri 19:00 | Fairfield | Wayne | 58-51 | W | School record 109 combined points; Tyrell Lewis 372 yards passing, tied school record of 7 TDs Accounted For (5 passing, 2 rushing); Teaunn Hunter 212 yards receiving |
| 38-28-1 |
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All data herein was compiled by Jim Becker, WHS '81
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